A-type potassium current modulated by A1 adenosine receptor in frog melanotrophs.

Adenosine acting at an A1 receptor decreases N-type calcium current in mouse motoneurons.

The neuromodulator adenosine is known to decrease neurotransmitter release at the neuromuscular junction by activation of an A1 adenosine receptor coupled to a pertussis toxin-sensitive G protein. Among the mechanisms that could contribute to the depression of neurotransmitter release is reduced entry of calcium through channels located in the presynaptic terminal. In the present study, we have...

PET imaging of adenosine A1 receptor occupancy.

Anti-Inflammatory Preconditioning by Agonists of Adenosine A1 Receptor

BACKGROUND Adenosine levels rise during inflammation and modulate inflammatory responses by engaging with four different G protein-coupled receptors. It is suggested that adenosine exhibits pro-inflammatory effects through its A(1) receptor (A(1)R), and anti-inflammatory effects through A(2A) receptor (A(2A)R). Therefore, understanding of the mechanisms that govern adenosine receptor regulation...

Anxiolytic properties of A1 adenosine receptor PAMs

Anxiety and anxiety disorders are among the most prevalent mental health conditions worldwide. Despite the high prevalence rates, anxiety is often an underestimated and undertreated clinical problem. Current treatment strategy for the management of anxiety mainly involves the use of selective serotonin reuptake inhibitors and benzodiazepines. Although widely prescribed and effective in reducing...

Adenosine A1 receptor antagonists at a fork in the road.

Up to one half of patients with chronic heart failure and two thirds of patients with acute heart failure have concomitant renal dysfunction—a clinicopathophysiologic association that has been termed the cardiorenal syndrome.1 When present, baseline renal impairment contributes to adverse outcomes in both ambulatory and hospital settings, and the attributable risk increases with progression of ...